This is a new route for me heading south from my place. 7th Avenue is a bit busy but you are not on it for very long. I did discover a nice little community garden on 7th and Kirkham. It is uphill on Clarendon and the payoff is great with a great view stretching from Candlestick point to the Golden Gate Bridge and beyond from the top. You can venture to the top of Tank Hill i you want at Twin Peaks and Stanyan.
This is a nice six mile run. Water on this jaunt is tough, plus it is the first time I have done it. There is water in Goldent Gate Park at the start but beyond that the only source I found were from faucets at homes.